Unbiased niche labeling maps immune-excluded niche in bone metastasis
Cell
LabNarrative concept · prepared as an independent design proposal
Publications
Recent and defining work
Selected research outputs that define the laboratory’s scientific direction and emerging programme.
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Inflammation- and resolution-programmed myeloid circuits govern therapeutic resistance in epithelial and mesenchymal triple-negative breast cancer
Journal of Clinical Investigation
ICAM1high Neutrophils Sculpt Tumor Evolution and Metastasis through Symbiotic Adhesion and Reverse Migration
Cancer Research
MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9+ monocyte-macrophage programming and durable anti-tumor immunity in triple negative breast cancer
bioRxiv (preprint)
Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization
Cell Genomics
Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis
Proceedings of the National Academy of Sciences
Leveraging preclinical models of metastatic breast cancer
BBA Reviews on Cancer
The tumor-immune ecosystem in shaping metastasis
Trends in Cancer
Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and responses to immunotherapy
Cell
Chemotherapy coupled to macrophage inhibition induces T-cell and B-cell infiltration and durable regression
Cancer Discovery
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms
Nature Cell Biology